A Narrative Review on the Anti-inflammatory Potential of Mamsyadi Yoga: Bridging Ayurveda and Modern Pharmacology
DOI:
https://doi.org/10.48165/IRJAY.2025.80904Keywords:
Agada, Anti-inflammatory, Mamsyadi Yoga, Shotha, Visha.Abstract
Background: There is a scarcity of Agada Yogas in the market which requires scientific exploration.
Aims and Objectives: The aim and objective of the study are to understand Shotha and inflammation and to study the probable efficacy of Mamsyadi Yoga in Shotha condition.
Materials and Methods: The pharmacodynamic properties of plants were taken from Ayurveda Pharmacopoeia of India and anti-inflammatory studies were taken from the past 10 years through Google Scholar and PubMed.
Discussion: The Mamsyadi Yoga is composed of 10 ingredients and each ingredients possess anti-inflammatory properties individually. As per Ayurveda also, the formulation was found to be dominant in Tikta Rasa, Laghu Guna, Ushna Veerya, and Katu Vipaka. Inflammation is the most common biological response when the body is exposed to microorganisms or toxic compound, or unwanted responses and is ultimately involved in the pathology of diseases initially.
Conclusion: Mamsyadi Yoga can be a useful Agada used in treating anti-inflammatory activities and implicating the principles of Agada in modern-day Visha.
Downloads
References
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Chikitsasthana, Vishachikitsa. Ch. 23., Ver. 190. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 659.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 1., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 87.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 4., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 8.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 1., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 197.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 1., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 194.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 1., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 79.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 1., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 189.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 3., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 229.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 5., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 31.
Government of India Ministry of Health and Family Welfare Department of Ayush. The Ayurvedic Pharmacopoeia of India. Vol. 2., Part. 1. India: Government of India Ministry of Health and Family Welfare Department of Ayush. p. 152.
Vagabhatta R. In: Kulkarni DA, Lachhmandas M, editors. Rasa Ratna Samuchchya. San Francisco: Internet Archive; 1998. p. 70.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Chikitsasthana, Shavyathuchikitsa. Ch. 12., Ver. 5–6. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 353–354.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Chikitsasthana, Shavyathuchikitsa. Ch. 12., Ver. 10. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 356.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Chikitsasthana, Shavyathuchikitsa. Ch. 12., Ver. 11. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 356.
Kiss AL. Inflammation in focus: The beginning and the end. Pathol Oncol Res. 2022;27:1610136. doi:10.3389/pore.2021.1610136.
Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121–126. doi:10.4103/aam.aam_56_18.
Medzhitov R. Inflammation 2010: New adventures of an old flame. Cell. 2010;140(6):771–776.
Jabbour HN, Sales KJ, Catalano RD, Norman JE. Inflammatory pathways in female reproductive health and disease. Reproduction. 2009;138:903–919. doi:10.1530/rep-09-0247.
Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007;147:227–235. doi:10.1111/j.1365-2249.2006.03261.x.
Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871–882. doi:10.1016/j.cell.2010.02.029.
Zhou Y, Hong Y, Huang H. Triptolide attenuates inflammatory response in membranous glomerulonephritis rat via downregulation of NF-κB signaling pathway. Kidney Blood Press Res. 2016;41:901–910. doi:10.1159/000452591.
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9:7204–7218. doi:10.18632/oncotarget.23208.
Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121–126. doi:10.4103/aam.aam_56_18.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Sootrasthana, Atreyabhadrakapiya Adhyaya. Ch. 26., Ver. 42. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 506.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Sootrasthana, Atreyabhadrakapiya Adhyaya. Ch. 26., Ver. 42. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 504.
Kashinath P, Gorakhnath C. Hindi commentary on Charaka Samhita, Sootrasthana, Atreyabhadrakapiya Adhyaya. Ch. 26., Ver. 42. Varanasi: Chaukhambha Sanskrita Sansthana; 2016. p. 507.
Singh RK, Vaishali, Panda SK, Murthy PN, Panigrahi G, Sharma PK, Gupta RK. Evaluation of anti-inflammatory potential of Nardostachys jatamansi rhizome in experimental rodents. J Coastal Life Med. 2014;2:112–118. doi:10.12980/jclm.2.2014j10.
Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002;2:7. doi:10.1186/1471-2210-2-7.
Rathore B, Jaggi K, Thakur SK, Mathur A, Mahdi F. Anti-inflammatory activity of Crocus sativus extract in experimental arthritis. Int J Pharm Sci Res. 2015;6(4):1473–1478. doi:10.13040/ijpsr.0975-8232.6(4).1473-78.
Dhar H, More SR, Ghongane BB. Anti-inflammatory activity of methanolic fraction of ethanolic extract of Crocus sativus stigmas in rats and mice. J Med Sci Clin Res. 2018;6(2):573–583.
Hossain H, Sariful M, Howlader I, Dey SK, Hira A, Arif A, Jahan F, Sarkar RP. Evaluation of anti-inflammatory activity of Cinnamomum tamala (Buch.-Ham.) leaves growing in Bangladesh. Int J Plant Soil Sci. 2012;1:114.
Mohanan M, Sakthi G, Anusha M, Vinothini. In vitro analysis of anti-inflammatory activity of Cinnamomum tamala and ointment formulation. Int J Res Trends Innov. 2022;7:1743–1744.
Abeysekera WP, Premakumara GA, Ratnasooriya WD, Abeysekera WK. Anti-inflammatory, cytotoxicity and antilipidemic properties: Novel bioactivities of true cinnamon (Cinnamomum zeylanicum Blume) leaf. BMC Complement Med Ther. 2022;22(1):259.
Prajapati JA, Humbal BR, Sadariya KA, Bhavsar SK, Thaker AM. Determination of in vivo anti-inflammatory potential of Cinnamomum zeylanicum oil in female Wistar rats. Pharma Innov. 2019;8(7):544–547.
Illuri R, Bethapudi B, Anandakumar S, Murugan S, Joseph JA, Mundkinajeddu D, Agarwal A, Agarwal A, Chandrasekaran CV. Anti-inflammatory activity of polysaccharide fraction of Curcuma longa extract (NR-INF-02). Antiinflamm Antiallergy Agents Med Chem. 2015;14:53–62.
Singh B, Sahu PM, Sharma RA. Anti-inflammation and antimicrobial constituents from the roots and their production in callus cultures of Valeriana jatamansi Jones. Curr Bioact Compd. 2020;16(5):671–680.
Dhande PP, Gupta AO, Jain S, Dawane JS. Anti-inflammatory and analgesic activities of topical formulations of Pterocarpus santalinus powder in rat model of chronic inflammation. J Clin Diagn Res. 2017;11(7):FF01–FF04.
Vasudevan CS, Kariyil BJ, Nair DA, Neerakkal IM. Screening of phytocompounds, molecular docking studies, and in vivo anti-inflammatory activity of heartwood aqueous extract of Pterocarpus santalinus Lf. Asian Pac J Trop Biomed. 2021;11(2):59–65.
Ratnamraju V, Dhande PP, Gupta AO, Vaz NS. Anti-inflammatory and analgesic activity of oral decoction of Pterocarpus santalinus bark wood powder in acute inflammation model. Int J Pharm Sci Res. 2018;9(10):4368–4372.
Baidya M, Maji HS, Bhatt S, Das D. In vitro evaluation of the thrombolytic and anti-inflammatory activity of Capparis sepiaria root extracts. J Med Pharm Allied Sci. 2022;11:4166–4171.
Kumar A, Agarwal K, Maurya AK, Shanker K, Bushra U, Tandon S, Bawankule DU. Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its anti-inflammatory, analgesic and antipyretic activities. Pharmacogn Mag. 2015;11(Suppl 1):S217.
Mehta V, Sharma A, Kailkhura P, Malairaman U. Antioxidant, anti-inflammatory, and antidiabetic activity of hydroalcoholic extract of Ocimum sanctum: An in vitro and in silico study. Asian J Pharm Clin Res. 2016;9:44–49.
Chaiyana W, Punyoyai C, Sriyab S, Prommaban A, Sirilun S, Maitip J, Chantawannakul P, Neimkhum W, Anuchapreeda S. Anti‐inflammatory and antimicrobial activities of fermented Ocimum sanctum Linn. extracts against skin and scalp microorganisms. Chem Biodivers. 2022;19(2):e202100799.
Ramamurthy J, Jayakumar ND. Anti-inflammatory, antioxidant effect and cytotoxicity of Ocimum sanctum intraoral gel for combating periodontal diseases. Bioinformation. 2020;16(12):1026–1032.
Sharma V, Bansal K, Reddy KR, Gautam DN, Singh NK, Rai H. Comparative evaluation of anti-inflammatory activity of Manahshila (realgar). J Complement Med Res. 2019;10:1–12.
Sharma V, Rai H, Gautam DN. In vitro anti-inflammatory activity of unpurified and purified Manahshila. Asian J Pharm Pharmacol. 2018;4:179–83.
